SML0625

AC253 trifluoroacetate salt

≥95% (HPLC)

• Synonym(e): Amylin Antagonist AC253
• Empirische Formel (Hill-System): C₁₂₂H₁₉₆N₄₀O₃₉ · xC₂HF₃O₂
• Molekulargewicht: 2847.11 (free base basis)
• NACRES: NA.77
• UNSPSC Code: 12352200
• eCl@ss: 32160701
• Assay: ≥95% (HPLC)
• Form: powder

Eigenschaften

• Quality Segment: 100
• assay: ≥95% (HPLC)
• form: powder
• color: white to off-white
• shipped in: wet ice
• storage temp.: −20°C

Beschreibung

Biochem/physiol Actions

AC253 is an antagonist of Amylin, one of the peptides in the Calcitonin-gene related peptide (CGRP) family. In recent studies. AC253 restored memories in brain cells taken from animals used as models of Alzheimer′s disease. Application of AC253 significantly enhanced long-term potentiation (LTP) when given to 6- to 12-month-old TgCRND8 mice that normally show blunted LTP. In other studies, AC25 neutralized the depressant effects of Aβ(1-42) on hippocampal LTP without affecting baseline transmission or LTP on its own.

AC253 is an antagonist of Amylin.

Features and Benefits

This compound is featured on the Calcitonin Gene-Related Peptides page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable