SML0668

Calhex 231 hydrochloride

≥98% (HPLC)

• Synonym(e): 4-Chloro-N-[(1S,2S)-2-[[(1R)-1-(1-naphthalenyl)ethyl]amino]cyclohexyl]-benzamide hydrochloride
• Empirische Formel (Hill-System): C₂₅H₂₇ClN₂O · HCl
• CAS-Nummer: 652973-93-8
• Molekulargewicht: 443.41
• NACRES: NA.77
• UNSPSC Code: 12352200
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: desiccated

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to beige
• solubility: DMSO: 15 mg/mL, clear
• storage temp.: −20°C

Beschreibung

Application

Calhex 231 hydrochloride has been used:

• as a calcium-sensing receptor (CaSR) antagonist: to test its impact on hearing in rats
• to test its effect on blood pressure levels spontaneous hypertensive rats (SHRs)
• to test its effect on acoustic response bias in zebrafish
• in Caco-2 cells to test its effect on, overexpression of fibroblast growth factor-23 (FGF-23 )

Biochem/physiol Actions

Calhex 231 is a negative allosteric modulator of the calcium sensing receptor CaSR.

Calhex 231 is a negative allosteric modulator of the calcium sensing receptor CaSR. Calhex 231 blocks calcium-induced accumulation of inositol phosphate with an IC₅₀ of 0.36 μM.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• Was ist los?: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable