SML0717

W-13

≥98% (HPLC)

• Synonym(e): N-(4-Aminobutyl)-5-chloro-2-naphthalenesulfonamide hydrochloride, W13
• Empirische Formel (Hill-System): C₁₄H₁₇ClN₂O₂S · HCl
• CAS-Nummer: 88519-57-7
• Molekulargewicht: 349.28
• NACRES: NA.77
• PubChem Substance ID: 329825589
• UNSPSC Code: 12352200
• MDL number: MFCD00058030
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: H₂O: 20 mg/mL, clear
• storage temp.: room temp
• SMILES string: Cl.NCCCCNS(=O)(=O)c1cccc2c(Cl)cccc12
• InChI: 1S/C14H17ClN2O2S.ClH/c15-13-7-3-6-12-11(13)5-4-8-14(12)20(18,19)17-10-2-1-9-16;/h3-8,17H,1-2,9-10,16H2;1H
• InChI key: IKMXJMNRHREPOD-UHFFFAOYSA-N

Beschreibung

Biochem/physiol Actions

W-13 is a membrane-permeable calmodulin antagonist.

W-13 is a membrane-permeable calmodulin antagonist. W-13 inhibits Ca²⁺-calmodulin-dependent phosphodiesterase and has been shown to inhibit the EGF-dependent activation of EGFR in N7xHERc fibroblasts.

W-13 has also been shown to inhibit the transcytosis of IgA, recycling of transferrin and overall alter the endocytic pathway in Madin-Darby canine kidney cells.

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Phosphodiesterases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• Was ist los?: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable