SML1207

GPBAR-A

≥98% (HPLC)

• Synonym(e): 4-[[3,5-Bis(trifluoromethyl)phenyl]methyl]-6-(2-fluorophenyl)-4,5-dihydro-pyrido[3,2-f]-1,4-oxazepin-3(2H)-one
• Empirische Formel (Hill-System): C₂₃H₁₅F₇N₂O₂
• CAS-Nummer: 877052-79-4
• Molekulargewicht: 484.37
• NACRES: NA.77
• PubChem Substance ID: 329825719
• UNSPSC Code: 51111800
• MDL number: MFCD27937760
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 5 mg/mL, clear (warmed)
• storage temp.: 2-8°C
• SMILES string: O=C(CO1)N(CC2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2)CC3=C1N=CC=C3C4=C(F)C=CC=C4
• InChI: 1S/C23H15F7N2O2/c24-19-4-2-1-3-17(19)16-5-6-31-21-18(16)11-32(20(33)12-34-21)10-13-7-14(22(25,26)27)9-15(8-13)23(28,29)30/h1-9H,10-12H2
• InChI key: ZIXNJVGTAXRKAP-UHFFFAOYSA-N

Beschreibung

Biochem/physiol Actions

GPBAR-A is a very potent agonist of the bile acid receptor GPBA (also known as TGR5).

GPBAR-A is a very potent agonist of the bile acid receptor GPBA (also known as TGR5). In murine primary intestinal cultures, GPBAR-A induces an elevation in intracellular cAMP and calcium levels, and stimulates secretion of GLP-1.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable