SML1707

Temoporfin

≥90% (HPLC)

• Synonym(e): 3,3′,3′′,3′′′-(7,8-Dihydro-21H,23H-porphine-5,10,15,20-tetrayl)tetrakis-phenol, 5,10,15,20-Tetra(m-hydroxyphenyl)chlorin
• Empirische Formel (Hill-System): C₄₄H₃₂N₄O₄
• CAS-Nummer: 122341-38-2
• Molekulargewicht: 680.75
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥90% (HPLC)
• Form: powder

Eigenschaften

• Quality Segment: 100
• assay: ≥90% (HPLC)
• form: powder
• color: dark brown to black
• solubility: DMSO: 2 mg/mL, clear (warmed)
• storage temp.: −20°C
• InChI: 1S/C44H32N4O4/c49-29-9-1-5-25(21-29)41-33-13-15-35(45-33)42(26-6-2-10-30(50)22-26)37-17-19-39(47-37)44(28-8-4-12-32(52)24-28)40-20-18-38(48-40)43(36-16-14-34(41)46-36)27-7-3-11-31(51)23-27/h1-17,19,21-24,46-47,49-52H,18,20H2
• InChI key: LYPFDBRUNKHDGX-UHFFFAOYSA-N

Beschreibung

General description

Temoporfin/(tetra[m-hydroxyphenyl]chlorin, m-THPC), is a hydrophobic second-generation photosensitizer. It is used in the palliative treatment of patients with advanced head and neck cancer by photodynamic therapy.

Biochem/physiol Actions

Temoporfin is a photosensitizer for the photodynamic therapy.

Temoporfin is a photosensitizer for the photodynamic therapy. Temoporfin has been used clinically to treat advanced head and neck squamous cell carcinoma, and is being investigated for use in several other cancers.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable