SML1874

DM-NOFD

≥98% (HPLC)

• Synonym(e): Dimethyl N-oxalyl-D-phenylalanine, N-(2-Methoxy-2-oxoacetyl)-D-phenylalanine methyl ester, N-Oxalyl-D-phenylalanine dimethyl ester
• Empirische Formel (Hill-System): C₁₃H₁₅NO₅
• CAS-Nummer: 865488-53-5
• Molekulargewicht: 265.26
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: oil

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: oil
• color: , colorless to dark yellow
• storage temp.: 2-8°C
• SMILES string: O=C(C(N[C@H](CC1=CC=CC=C1)C(OC)=O)=O)OC
• InChI: 1S/C13H15NO5/c1-18-12(16)10(14-11(15)13(17)19-2)8-9-6-4-3-5-7-9/h3-7,10H,8H2,1-2H3,(H,14,15)/t10-/m1/s1
• InChI key: CAUUPQLNYYFMOQ-SNVBAGLBSA-N

Beschreibung

General description

Dimethyl N-oxalyl-D-phenylalanine (DM-NOFD) is a small FIH (factor-inhibiting) inhibitor molecule.

Biochem/physiol Actions

DM-NOFD is a cell penetrant, prodrug of NOFD a potent and selective inhibitor of an asparaginyl hydroxylase FIH (factor-inhibiting HIF).

DM-NOFD is a cell penetrant, prodrug of NOFD a potent and selective inhibitor of an asparaginyl hydroxylase FIH (factor-inhibiting HIF). DM-NOFD efficiently reduces HIF1a CAD (C-terminal activating domain) hydroxylation in MCF-7 cells.

Sicherheitshinweise

• Lagerklasse: 10 - Combustible liquids
• Was ist los?: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable