SML1920

ML364

≥98% (HPLC)

• Synonym(e): 2-(4-Methylphenylsulfonamido)-N-(4-phenylthiazol-2-yl)-4-(trifluoromethyl)benzamide, 2-[[(4-Methylphenyl)sulfonyl]amino]-N-(4-phenyl-2-thiazolyl)-4-(trifluoromethyl)-benzamide
• Empirische Formel (Hill-System): C₂₄H₁₈F₃N₃O₃S₂
• CAS-Nummer: 1991986-30-1
• Molekulargewicht: 517.54
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 20 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: FC(F)(F)c1cc(c(cc1)C(=O)Nc3[s]cc(n3)c4ccccc4)N[S](=O)(=O)c2ccc(cc2)C
• InChI key: QZUGMNXETPARLI-UHFFFAOYSA-N

Beschreibung

Biochem/physiol Actions

ML364 is a potent and specific inhibitor of the deubiquitinase USP2 that induces cellular Cyclin D1 degradation in HCT116 colorectal cancer cells, followed by cell cycle arrest and apoptosis. Also, ML364 inhibits homologous recombination (HR)-mediated DNA repair.

Potent and specific inhibitor of the deubiquitinase USP2

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable