SML1929

Equisetin

(Fusarium equiseti), ≥97% (HPLC)

• Synonym(e): (3E,5S)-3-[[(1S,2R,4aS,6R,8aR)-1,6-dimethyl-2-[(E)-prop-1-enyl]-4a,5,6,7,8,8a-hexahydro-2H-naphthalen-1-yl]-hydroxymethylidene]-5-(hydroxymethyl)-1-methylpyrrolidine-2,4-dione
• Empirische Formel (Hill-System): C₂₂H₃₁NO₄
• CAS-Nummer: 57749-43-6
• Molekulargewicht: 373.49
• NACRES: NA.77
• UNSPSC Code: 12352200
• eCl@ss: 32150313
• Assay: ≥97% (HPLC)
• Form: powder

Eigenschaften

• Quality Segment: 200
• biological source: (Fusarium equiseti)
• assay: ≥97% (HPLC)
• form: powder
• solubility: DMSO: soluble 1 mg/mL, chloroform: soluble 5 mg/mL
• shipped in: ambient
• storage temp.: −20°C
• SMILES string: C[C@H]1C[C@]2([H])[C@@]([C@](C)(/C(O)=C3C([C@H](CO)N(C)C/3=O)=O)[C@H](/C=C/C)C=C2)([H])CC1
• InChI: 1S/C22H31NO4/c1-5-6-15-9-8-14-11-13(2)7-10-16(14)22(15,3)20(26)18-19(25)17(12-24)23(4)21(18)27/h5-6,8-9,13-17,24,27H,7,10-12H2,1-4H3/b6-5+/t13-,14-,15-,16-,17+,22-/m1/s1
• InChI key: SLOQQJFOWFUUMP-KNQICWOTSA-N

Beschreibung

Biochem/physiol Actions

Equisetin is a tetramic acid analog derived from Fusarium equisti. Equisetin is mainly known for its antibiotic and cytotoxic activity and for its inhibitory effect on HIV-1 integrase. Inhibition of HIV integrase by Equisetin was reported with IC₅₀ values of 5-20 μM. Moreover, it was shown that Equisetin specifically inhibits the substrate anion carriers of the inner membrane of mitochondria and acts nonspecifically on protein membranes and protein hydrophobic domains. In addition, it was demonstrated that Equisetin causes phytotoxicity by causing root Necrosis and was also identified in a mycotoxin cocktail associated with cattle feeding problems.

Equisetin is a tetramic acid analog derived from Fusarium equisti.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable