SML2047

BPAM344

≥98% (HPLC)

• Synonym(e): BPAM344, 4-Cyclopropyl-3,4-dihydro-7-fluoro-2H-1,2,4-benzothiadiazine 1,1-dioxide
• Empirische Formel (Hill-System): C₁₀H₁₁FN₂O₂S
• CAS-Nummer: 1204572-55-3
• Molekulargewicht: 242.27
• UNSPSC Code: 12352200
• NACRES: NA.77
• eCl@ss: 32150313
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• storage temp.: 2-8°C
• SMILES string: O=S1(C2=CC(F)=CC=C2N(C3CC3)CN1)=O
• InChI: 1S/C10H11FN2O2S/c11-7-1-4-9-10(5-7)16(14,15)12-6-13(9)8-2-3-8/h1,4-5,8,12H,2-3,6H2
• InChI key: FLTMTBPCYAZIKM-UHFFFAOYSA-N

Beschreibung

Biochem/physiol Actions

BPAM344 is a potent positive allosteric modulator (PAM) on the three KAR subunits GluK1b, GluK2a, and GluK3a. BPAM344 potentiates glutamate-evoked currents of GluK2a 21-fold, and noticeably decreases desensitization kinetics (from 5.5 to 775 ms).

Potent positive allosteric modulator (PAM) on the three KAR subunits GluK1b, GluK2a, and GluK3a

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable