SML2106

Roflupram

≥98% (HPLC)

• Synonym(e): 1-[4-(Difluoromethoxy)-3-[(tetrahydro-3-furanyl)oxy]phenyl]-3-methyl-1-butanone, FFPM, ZL-n-91
• Empirische Formel (Hill-System): C₁₆H₂₀F₂O₄
• CAS-Nummer: 1093412-18-0
• Molekulargewicht: 314.32
• UNSPSC Code: 51111800
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: oil

Eigenschaften

• assay: ≥98% (HPLC)
• form: oil
• color: colorless to light brown
• storage temp.: 2-8°C
• SMILES string: O=C(CC(C)C)C1=CC=C(OC(F)F)C(OC2CCOC2)=C1
• InChI key: IXURVUHDDXFYDR-UHFFFAOYSA-N

Beschreibung

Biochem/physiol Actions

Anti-inflammatory phosphodiesterase 4 (PDE4) inhibitor

Roflupram (FFPM) is a potent anti-inflammatory phosphodiesterase 4 (PDE4) inhibitor that was found to suppress inflammasome activation in microglial cells by enhancing autophagy. In microglial BV-2 cells roflupram enhanced the level of microtubule-associated protein 1 light chain 3 II (LC3-II) and decreased the autophagy receptor ubiquitin-binding protein p62 (SQSTM1), enhancing autophagy, reducing the activation of inflammasome and suppressing the production of IL-1β. Roflupram (FFPM) was found to reverse learning and memory deficits in APP/PS1 transgenic mice.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• Was ist los?: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable