SML2144

TB5

≥98% (HPLC)

• Synonym(e): (2E)-1-(5-bromothiophen-2-yl)-3-[4-(dimethylamino)phenyl]prop-2-en-1-one
• Empirische Formel (Hill-System): C₁₅H₁₄BrNOS
• CAS-Nummer: 948841-07-4
• Molekulargewicht: 336.25
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD30718167
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: yellow to orange
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: CN(C)C(C=C1)=CC=C1/C=C/C(C2=CC=C(Br)S2)=O
• InChI: 1S/C15H14BrNOS/c1-17(2)12-6-3-11(4-7-12)5-8-13(18)14-9-10-15(16)19-14/h3-10H,1-2H3/b8-5+
• InChI key: PTLDLBSWTKNYCY-VMPITWQZSA-N

Beschreibung

Biochem/physiol Actions

Potent and selective reversible inhibitor of monoamine oxidase B (MAOB)

TB5 is a potent and selective reversible inhibitor of monoamine oxidase B (MAOB) with a Ki value of 110 nM. A reversible inhibitor should have an advantage over irreversible inhibitors such as selegiline in limiting side effects. Parallel artificial membrane permeation (PAMPA) assays indicated TB5 should be able to cross the blood–brain barrier. TB5 was found nontoxic to cells.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• Was ist los?: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable