SML2172

CLP290

≥98% (HPLC)

• Synonym(e): [5-Fluoro-2-[(Z)-(2-hexahydropyridazin-1-yl-4-oxo-thiazol-5-ylidene)methyl]phenyl] pyrrolidine-1-carboxylate
• Empirische Formel (Hill-System): C₁₉H₂₁FN₄O₃S
• CAS-Nummer: 1181083-81-7
• Molekulargewicht: 404.46
• UNSPSC Code: 12352200
• MDL number: MFCD28166314
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: FC1=CC=C(/C=C2C(N=C(N3NCCCC3)S/2)=O)C(OC(N4CCCC4)=O)=C1
• InChI: 1S/C19H21FN4O3S/c20-14-6-5-13(15(12-14)27-19(26)23-8-3-4-9-23)11-16-17(25)22-18(28-16)24-10-2-1-7-21-24/h5-6,11-12,21H,1-4,7-10H2/b16-11-
• InChI key: DIXMMXNNKLCLOM-WJDWOHSUSA-N

Beschreibung

Biochem/physiol Actions

CLP290 is a small molecule enhancer of KCC2 activity. It is an orally active and more bioavailable precursor of the selective K⁺-Cl^- cotransporter KCC2 activator CLP257. CLP290 was recently shown to restore Cl^- transport and rescue morphine-induced hyperalgesia (MIH) in morphine-treated rats.

Enhancer of K⁺-Cl^- cotransporter KCC2 activity, precursor of chloride extrusion enhancer CLP257

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• Was ist los?: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable