SML2184

Kevetrin hydrochloride

≥98% (HPLC)

• Synonym(e): Kevetrin hydrochloride, 4-Isothioureidobutyronitrile hydrochloride, Carbamimidothioic acid 3-cyanopropyl ester hydrochloride, NSC 525990 HCl
• Empirische Formel (Hill-System): C₅H₉N₃S · HCl
• CAS-Nummer: 66592-89-0
• Molekulargewicht: 179.67
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD22572767
• eCl@ss: 32150313
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: desiccated

Eigenschaften

• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to beige
• solubility: H₂O: 2 mg/mL, clear
• storage temp.: −20°C
• SMILES string: NC(SCCCC#N)=N.Cl
• InChI: 1S/C5H9N3S.ClH/c6-3-1-2-4-9-5(7)8;/h1-2,4H2,(H3,7,8);1H
• InChI key: NCXJZJFDQMKRKM-UHFFFAOYSA-N

Beschreibung

Biochem/physiol Actions

Kevetrin is an activator/stabilizer of wild type p53 tumor suppressor protein in human lung carcinoma and ovarian cancer cells that induces cell cycle arrest and apoptosis. Additionally Kevetrin down-regulates oncogenic mutant p53 in OVCAR-3 ovarian cancer cells. Kevetrin inhibits tumor growth in xenograft model of ovarian cancer.

wild type p53 stabilizer

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable