SML2326

MSC1094308

≥98% (HPLC)

• Synonym(e): N-((6-Fluoro-2,3,4,9-tetrahydro-1H-carbazol-3-yl)methyl)-4,4-bis(4-fluorophenyl)butan-1-amine, N-[4,4-Bis(4-fluorophenyl)butyl]-6-fluoro-2,3,4,9-tetrahydro-1H-carbazole-3-methanamine
• Empirische Formel (Hill-System): C₂₉H₂₉F₃N₂
• CAS-Nummer: 2219320-08-6
• Molekulargewicht: 462.55
• UNSPSC Code: 12352200
• NACRES: NA.21
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: FC1=CC=C(C(C2=CC=C(F)C=C2)CCCNCC3CCC(NC4=C5C=C(F)C=C4)=C5C3)C=C1
• InChI key: OCZIMUMAPGQEBH-UHFFFAOYSA-N

Beschreibung

Biochem/physiol Actions

MSC1094308 is a reversible, non-ATP-competitive, type I AAA ATPase VPS4B-selective allosteric inhibitor (IC50 = 0.71 μM) with =10-fold reduced potency toward the type II AAA ATPase VCP/p97 and NSF (IC50 = 7.2 and >40 μM, respectively). MSC1094308 specifically inhibits p97-mediated Ub-GFP degradation without affecting proteasome-dependent ODD-luc degradation using a dual reporter HeLa cell line (10 μM) and exhibits comparable efficacy as DBeQ against 50 ng/mL TNFα-induced IκBα degradation in HeLa cells (10 μM).

Reversible, non-ATP-competitive, AAA ATPase VPS4B & VCP/p97 allosteric inhibitor against cellular p97, but not proteasome, substrates degradation.

MSC1094308 binding to drugable hotspot of p97 has the ability to block the D2 ATPase activity.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable