SML2469

Oxanthroquinone G01

≥98% (HPLC)

• Synonym(e): 9,10-Dihydro-8-hydroxy-3-methoxy-1,7-dimethyl-9,10-dioxo-2-anthracenecarboxylic acid ethyl ester, G01
• Empirische Formel (Hill-System): C₂₀H₁₈O₆
• CAS-Nummer: 1616622-15-1
• Molekulargewicht: 354.35
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• assay: ≥98% (HPLC)
• form: powder
• color: faint yellow to dark orange
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: O=C1C2=C(C=C(OC)C(C(OCC)=O)=C2C)C(C3=CC=C(C)C(O)=C31)=O
• InChI: 1S/C20H18O6/c1-5-26-20(24)15-10(3)14-12(8-13(15)25-4)18(22)11-7-6-9(2)17(21)16(11)19(14)23/h6-8,21H,5H2,1-4H3
• InChI key: NWSATONEZZIFDE-UHFFFAOYSA-N

Beschreibung

Biochem/physiol Actions

Oxanthroquinone G01 is a potent inhibitor of KRAS and NRAS plasma membrane localization that potently inhibits proliferation of KRAS transformed cancer cells. Oxanthroquinone G01 also inhibits recycling of epidermal growth factor receptor and transferrin receptor, but has no influence on cholera toxin internalization. It also increases cellular levels of sphingomyelin and and ceramide.

potent inhibitor of KRAS and NRAS plasma membrane localization, putative RAS inhibitor

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• Was ist los?: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable