SML2544

NSC49652

≥98% (HPLC)

• Synonym(e): (2E)-1-(2-Hydroxyphenyl)-3-(3-pyridinyl)-2-propen-1-one, (E)-1-(2-Hydroxyphenyl)-3-(pyridin-3-yl)-2-propen-1-one
• Empirische Formel (Hill-System): C₁₄H₁₁NO₂
• CAS-Nummer: 908563-68-8
• Molekulargewicht: 225.24
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD00499170
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: OC1=CC=CC=C1C(/C=C/C2=CN=CC=C2)=O
• InChI: 1S/C14H11NO2/c16-13-6-2-1-5-12(13)14(17)8-7-11-4-3-9-15-10-11/h1-10,16H/b8-7+
• InChI key: CRWNZUBUBIULHB-BQYQJAHWSA-N

Beschreibung

Biochem/physiol Actions

NSC49652 is a orally active, potent and selective inhibitor of death receptor p75NTR (p75 neurotrophin receptor) that targets the interfaces between transmembrane domains (TMDs). NSC49652 induces profound conformational changes and triggers p75NTR dependent cancer cell death. It inhibits the growth of cancer in melanoma mouse model.

orally active, potent and selective inhibitor of death receptor p75NTR that targets the interfaces between transmembrane domains

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable