SML2552

AP-C5

≥98% (HPLC)

• Synonym(e): 4-[4-(1H-Imidazol-1-yl)phenyl]-N-2-propyn-1-yl-2-pyrimidinamine
• Empirische Formel (Hill-System): C₁₆H₁₃N₅
• CAS-Nummer: 2234272-10-5
• Molekulargewicht: 275.31
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: C#CCNC1=NC=CC(C2=CC=C(N3C=NC=C3)C=C2)=N1
• InChI: 1S/C16H13N5/c1-2-8-18-16-19-9-7-15(20-16)13-3-5-14(6-4-13)21-11-10-17-12-21/h1,3-7,9-12H,8H2,(H,18,19,20)
• InChI key: QKHQFSQJQKGFAA-UHFFFAOYSA-N

Beschreibung

Biochem/physiol Actions

AP-C5 is a potent and selective inhibitor of the guanosine 3′,5′-cyclicmonophosphate (cGMP)-dependent protein kinase II (cGKII)that selectively blocks cGKII dependent phosphorylation of the vasodilator-stimulated phosphoprotein (VASP) in intestinal organoids. AP-C5 mitigates secretory response provoked by the GCC-activating Escherichia coli heat-stable toxin (STa) in mouse small intestinal tissue.

potent and selective inhibitor of the guanosine 3′,5′-cyclicmonophosphate (cGMP)-dependent protein kinase II (cGKII)

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable