SML2640

YZ129

≥98% (HPLC)

• Synonym(e): 4-(6-Isoquinolinylamino)-1,2-naphthalenedione, 4-(Isoquinolin-6-ylamino)naphthalene-1,2-dione, YZ-129, YZ129
• Empirische Formel (Hill-System): C₁₉H₁₂N₂O₂
• CAS-Nummer: 1643120-60-8
• Molekulargewicht: 300.31
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD31813767
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• assay: ≥98% (HPLC)
• form: powder
• color: faint brown-red to dark red
• solubility: DMSO: 0.5 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: N(c3cc4c(cncc4)cc3)C1=CC(=O)C(=O)c2c1cccc2
• InChI key: NYDMVPHEEBVAHT-UHFFFAOYSA-N

Beschreibung

Biochem/physiol Actions

Hsp90 inhibitor with anti-cancer efficacy in vitro and in vivo.

YZ129 is an ATP site-targeting Hsp90 inhibitor (IC50 = 29.5 nM against 2.5 nM geldanamycin-FITC for binding human HSP90α) that prevents thapsigargin (1 μM)-induced NFAT nuclear translocation in HeLa cells (IC50 = 820 nM) by blocking HSP90 client calcineurin-mediated NFAT dephosphorylation. YZ129 (5 μM; 24-48 hr) suppresses U87 glioblastoma (GBM) cell migration and proliferation as a result of G2/M arrest and apoptosis induction. Daily intraperitoneal administration is efficacious against U87 xenografts (s.c.; bilateral posterior limbs)-derived tumor growth in mice in vivo.

Other Notes

Product may exist in a Tautomeric Form.

Sicherheitshinweise

• Lagerklasse: 13 - Non Combustible Solids
• Was ist los?: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable