The stability of this product in solution, including DMSO, has not been investigated. Other sources indicate that solutions prepared at 40 mg/mL in dry DMSO are stable for 1 year at −20°C. This information has not been validated. As a general practice, store solutions in working aliquots. Avoid repeated freeze/thaw cycles.
Fortfahren mit
SML2647
CA3
≥97% (HPLC)
Synonym(e):
1,1′-[[9-(Hydroxyimino)-9H-fluorene-2,7-diyl]bis(sulfonyl)]bis-piperidine, 2,7-bis(1-Piperidinylsulfonyl)-9H-fluoren-9-one oxime, CIL56
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| Größe/SKU | Verfügbarkeit | Preis |
|---|---|---|
5 mg | Warenkorb auf Verfügbarkeit prüfen | € 96,30 |
25 mg | Warenkorb auf Verfügbarkeit prüfen | € 311,00 |
Über diesen Artikel
Empirische Formel (Hill-System):
C23H27N3O5S2
CAS-Nummer:
Molekulargewicht:
489.61
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥97% (HPLC)
Form:
powder
Technischer Dienst
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Unterstützung erhaltenassay
≥97% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
−20°C
SMILES string
[S](=O)(=O)(N5CCCCC5)c1cc2c(cc1)c3c(cc(cc3)[S](=O)(=O)N4CCCCC4)C2N=O
InChI
1S/C23H27N3O5S2/c27-24-23-21-15-17(32(28,29)25-11-3-1-4-12-25)7-9-19(21)20-10-8-18(16-22(20)23)33(30,31)26-13-5-2-6-14-26/h7-10,15-16,23H,1-6,11-14H2
InChI key
YLRXSLQNJCJWGZ-UHFFFAOYSA-N
Biochem/physiol Actions
CA3 is a potent and selective inhibitor of YAP1 (Hippo co-activator Yes-associated protein 1) that inhibits YAP1 expression and transcriptional activity in esophageal adenocarcinoma (EAC) cell lines. CA3 potently inhibits growth, induces apoptosis in radiation resistant CSC (cancer stem cell) enriched EAC cells. It inhibits tumor growth of in xenograft model with no apparent toxicity.
potent and selective inhibitor of YAP1 that inhibits YAP1 expression and transcriptional activity in EAC cell lines
1 of 1
Dieser Artikel | |||
|---|---|---|---|
| description ≥97% (HPLC) | description affinity isolated antibody | description for serum, plasma and cell culture supernatants | description Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution, Ab2 |
| form powder | form buffered aqueous solution | form - | form buffered aqueous glycerol solution |
| assay ≥97% (HPLC) | assay - | assay - | assay - |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
| solubility DMSO: 2 mg/mL, clear | solubility - | solubility - | solubility - |
| color white to beige | color - | color - | color - |
Lagerklasse
11 - Combustible Solids
WGK
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
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