SML2701

CBA

≥98% (HPLC)

• Synonym(e): 4-Chloro-2-[[2-(2-chlorophenoxy)acetyl]amino]benzoic acid
• Empirische Formel (Hill-System): C₁₅H₁₁Cl₂NO₄
• CAS-Nummer: 351424-20-9
• Molekulargewicht: 340.16
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD01930120
• eCl@ss: 32160701
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: Clc1c(cccc1)OCC(=O)Nc2c(ccc(c2)Cl)C(=O)O
• InChI: 1S/C15H11Cl2NO4/c16-9-5-6-10(15(20)21)12(7-9)18-14(19)8-22-13-4-2-1-3-11(13)17/h1-7H,8H2,(H,18,19)(H,20,21)
• InChI key: CVQCJPCMPGKEDH-UHFFFAOYSA-N

Beschreibung

Biochem/physiol Actions

CBA (Compound 5; 4-Chloro-2-[[2-(2-chlorophenoxy)acetyl]amino]benzoic acid) is a cell penetrant, potent and selective TRPM4 (Transient receptor potential melastatin member 4) inhibitor that shows not significant activity against TRPM5, TRPM7, TRPM8, TRPV1, TRPV3, TRPV6. It rescues functional expression of mutant A432T TRPM4 in cells. CBA (Compound 5) exhibits neuroprotective activity against glutamate-induced neurodegeneration.

cell penetrant, potent and selective TRPM4 (Transient receptor potential melastatin member 4) inhibitor

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable