SML2816

BS46 bromide

≥98% (HPLC)

• Synonym(e): (1R,2R,4S,5S,7S)-7-[({4-Fluoro-2-(thiophen-2-yl)phenyl}carbamoyl)oxy]-9,9-dimethyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-9-ium bromide
• Empirische Formel (Hill-System): C₂₀H₂₂BrFN₂O₃S
• Molekulargewicht: 469.37
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: −20°C
• SMILES string: FC1=CC=C(NC(O[C@@H]2C[C@H]([C@@H]3[C@H]4O3)[N+](C)(C)[C@H]4C2)=O)C(C5=CC=CS5)=C1.[Br-]

Beschreibung

Biochem/physiol Actions

BS46 is a highly potent and selective muscarinic acetylcholine receptor antagonist that exhibits 33-fold preference for M3R (M3 muscarinic acetylcholine receptor) over M2R. It fully inhibits carbachol-induced inositol monophosphate accumulation as well as ?-arrestin recruitment at M3Rs. BS46 exhibits 100,000-fold selectivity for muscarinic receptors against 21 aminergic and peptidergic GPCRs.

highly potent and selective M3 muscarinic acetylcholine receptor (M3R) antagonist that exhibits 33-fold preference for M3R over M2R

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• Was ist los?: WGK 3