SML3189

BMS-265246

≥98% (HPLC)

• Synonym(e): (4-Butoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)(2,6-difluoro-4-methylphenyl)methanone, BMS 265246, BMS265246
• Empirische Formel (Hill-System): C₁₈H₁₇F₂N₃O₂
• CAS-Nummer: 582315-72-8
• Molekulargewicht: 345.34
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD22420825
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: FC1=C(C(F)=CC(C)=C1)C(C2=C(C3=C(N=C2)NN=C3)OCCCC)=O
• InChI: 1S/C18H17F2N3O2/c1-3-4-5-25-17-11(8-21-18-12(17)9-22-23-18)16(24)15-13(19)6-10(2)7-14(15)20/h6-9H,3-5H2,1-2H3,(H,21,22,23)
• InChI key: SCFMWQIQBVZOQR-UHFFFAOYSA-N

Beschreibung

Biochem/physiol Actions

ATP site-targeting, potent and CDK1/CDK2-selective cyclin-dependent kinase inhibitor with anti-cancer efficacy in A2780 ovarian cancer culture.

BMS-265246 is an ATP site-targeting, potent and CDK1/2-selective cyclin-dependent kinase inhibitor (IC50 = 6 nM/CDK1, 9 nM/CDK2, 230 nM/CDK4) with anti-cancer efficacy in A2780 ovarian cancer culture (IC50 = 760 nM).

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• Was ist los?: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable