SML3207

MB05032

≥98% (HPLC)

• Synonym(e): 2-Amino-5-isobutyl-4-[5-phosphono-2-furanyl]thiazole, 5-[2-Amino-5-(2-methylpropyl)-4-thiazolyl]-2-furanyl]phosphonic acid, CS-917 active drug, MB 05032, MB-05032, MB-06322 active drug, MB06322 active drug, [5-[2-Amino-5-(2-methylpropyl)-1,3-thiazol-4-yl]furan-2-yl]phosphonic acid
• Empirische Formel (Hill-System): C₁₁H₁₅N₂O₄PS
• CAS-Nummer: 261365-11-1
• Molekulargewicht: 302.29
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD14584901
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear (warmed)
• storage temp.: −20°C
• SMILES string: [P](=O)(O)(O)c1[o]c(cc1)c2nc([s]c2CC(C)C)N
• InChI: 1S/C11H15N2O4PS/c1-6(2)5-8-10(13-11(12)19-8)7-3-4-9(17-7)18(14,15)16/h3-4,6H,5H2,1-2H3,(H2,12,13)(H2,14,15,16)
• InChI key: XJMYIJPPDSZOPN-UHFFFAOYSA-N

Beschreibung

Biochem/physiol Actions

AMP site-targeting, potent and selective fructose-1,6-bisphosphatase (FBPase) inhibitor that suppresses cellular gluconeogenesis (GNG).

MB05032 is an AMP site-targeting, potent and selective fructose-1,6-bisphosphatase (FBPase) inhibitor (rec hum liver FBPase IC50 = 16 nM, purified hum muscle/rat liver FBPase IC50 = 29/61 nM) with no potency toward glycogen phosphorylase or AMP-activated protein kinase. MB05032 inhibits cellular (rat/human hepotocytes IC50/glucose gluconeogenesis (GNG) substrate = 7.8 ?M/lactate & pyruvate/rat hepotocytes, 47.5 μM/lactate/human hepotocytes).

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• Was ist los?: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable