SML3282

HS-1371 trifluoroacetate salt

≥98% (HPLC)

• Synonym(e): 4-(4-methylphenoxy)-7-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-quinoline trifluoroacetate salt, 7-(1-(Piperidin-4-yl)-1H-pyrazol-4-yl)-4-(p-tolyloxy)quinoline trifluoroacetate salt, HS 1371, HS1371
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD31813738
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: , White to very dark gray
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: CC(C=C1)=CC=C1OC2=CC=NC3=CC(C4=CN(C5CCNCC5)N=C4)=CC=C23
• InChI: 1S/C24H24N4O/c1-17-2-5-21(6-3-17)29-24-10-13-26-23-14-18(4-7-22(23)24)19-15-27-28(16-19)20-8-11-25-12-9-20/h2-7,10,13-16,20,25H,8-9,11-12H2,1H3
• InChI key: VPVLPCIBKVWFDT-UHFFFAOYSA-N

Beschreibung

Biochem/physiol Actions

HS-1371 is a potent ATP-competitive RIP3 (RIPK3) kinase inhibitor (IC50 = 20.8 nM, [ATP] = 10 μM) that blocks RIP3 S227 autophosphorylation and selectively suppresses TNF/SMAC mimetic/Z-VAD-FMK agonist treatment-induced necroptosis induction in HT-29 cultures (by 44.4% at 1 μM, by 77.7% at 5 μM) in a RIP3- and MLKL-dependent manner.

Potent ATP-competitive RIP3 (RIPK3) kinase inhibitor that suppresses necroptosis in a RIP3- and MLKL-dependent manner.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• Was ist los?: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable