SML3306

BAY-390

≥98% (HPLC)

• Synonym(e): (1R,2R)-2-(4-Fluorophenylamino)-1-(trifluoromethyl)cyclohexanol, BAY 390, BAY390
• Empirische Formel (Hill-System): C₁₃H₁₅F₄NO
• CAS-Nummer: 2741956-55-6
• Molekulargewicht: 277.26
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: oil

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: oil
• color: yellow to orange
• storage temp.: 2-8°C
• SMILES string: FC1=CC=C(C=C1)N[C@H]2[C@@](C(F)(F)F)(CCCC2)O
• InChI key: IESAJAZKMLPVIB-VXGBXAGGSA-N

Beschreibung

Biochem/physiol Actions

BAY-390 is an orally active, potent and selective TRPA1 inhibitor (cellular Ca++ influx IC50 in nM by FLIPR = 16/hu, 19/monkey, 63/rat, 68/guinea pig, 73/mu, 81/dog; IC50 = 5.6 µM/hTRPC5, >25 µM/human TRPV1/4, TRPC3/6, KCNK9 (TASK-3), CACNA1H (Cav3.2)) that shows in vivo efficacy in animal models of inflammatory pain (30 or 90 mg/kg mice, p.o.) and neurogenic pain (30 or 90 mg/kg rats, b.i.d. p.o.).

Oally active, potent and selective TRPA1 inhibitor with in vivo efficacy in inflammatory and neurogenic pain models.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• Was ist los?: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable