SML3308

RyR1-selective inhibitor 1

≥98% (HPLC)

• Synonym(e): 5,8-Dihydro-5-octyl-8-oxo-1,3-dioxolo[4,5-g]quinoline-7-carboxylic acid sodium salt
• Empirische Formel (Hill-System): C₁₉H₂₂NO₅·Na
• Molekulargewicht: 367.37
• NACRES: NA.77
• UNSPSC Code: 12352200
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: desiccated

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to beige
• solubility: H₂O: 2 mg/mL, clear (Warmed)
• storage temp.: room temp

Beschreibung

Biochem/physiol Actions

Potent and selective inhibitor of the type 1 ryanodine receptor (RyR1)

RyR1-selective inhibitor 1 (6,7-(methylenedioxy)-1-octyl-4-quinolone-3-carboxylic acid) potently and selectively inhibits the type 1 ryanodine receptor (RyR1). It prevents and treats malignant hyperthermia and heat stroke in several mouse models. RyR1-selective inhibitor 1 decreases resting intracellular Ca2+, inhibits halothane- and isoflurane-induced Ca2+ release, and suppresses caffeine-induced contracture in skeletal muscle.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable