SML3323

MS9715

≥98% (HPLC)

• Synonym(e): (2S,4R)-1-((S)-2-(9-(4-((4-(5-(7-fluoroquinolin-4-yl)-1-methyl-1H-imidazol-4-yl)-3,5-dimethylbenzyl)amino)butanamido)nonanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide
• Empirische Formel (Hill-System): C₅₈H₇₄FN₉O₅S
• Molekulargewicht: 1028.33
• UNSPSC Code: 12352200
• NACRES: NA.32
• Assay: ≥98% (HPLC)

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: CC1=C(C(C)=CC(CNCCCC(NCCCCCCCCC(N[C@H](C(N2[C@@H](C[C@H](C2)O)C(N[C@H](C3=CC=C(C=C3)C4=C(N=CS4)C)C)=O)=O)C(C)(C)C)=O)=O)=C1)C5=C(N(C=N5)C)C6=CC=NC7=C6C=CC(F)=C7
• InChI: 1S/C58H74FN9O5S/c1-36-28-40(29-37(2)51(36)52-53(67(8)34-63-52)46-24-27-61-47-30-43(59)22-23-45(46)47)32-60-25-15-17-49(70)62-26-14-12-10-9-11-13-16-50(71)66-55(58(5,6)7)57(73)68-33-44(69)31-48(68)56(72)65-38(3)41-18-20-42(21-19-41)54-39(4)64-35-74-54/h18-
• InChI key: RWXCSOWWDBANDF-LPFSXYLXSA-N

Beschreibung

Biochem/physiol Actions

MS9715 is a potent and highly selective degrader (PROTAC) of NSD3 (Nuclear receptor binding SET domain protein 3) that effectively depletes NSD3 and the associated cMyc oncogenic node. MS9715 comprised of NSD3 antagonist BI-9321 linked to an E3 ligase VHL ligand. It potently inhibits growth of NSD3-dependent hematological cancer cells.

Potent and highly selective degrader (PROTAC) of NSD3 that effectively depletes NSD3 and the associated cMyc oncogenic node

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• Was ist los?: WGK 3