SML3333

Dianhydrogalactitol

≥95% (HPLC)

• Synonym(e): 1,2:5,6-Dianhydrogalactitol, 1,2:5,6-Diepoxydulcitol, DAG, NSC-132313, VAL-083
• Empirische Formel (Hill-System): C₆H₁₀O₄
• CAS-Nummer: 23261-20-3
• Molekulargewicht: 146.14
• UNSPSC Code: 12352200
• MDL number: MFCD01725532
• Assay: ≥95% (HPLC)
• Form: powder

Eigenschaften

• Quality Segment: 100
• assay: ≥95% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: −20°C
• SMILES string: O[C@H]([C@@]1(CO1)[H])[C@H]([C@]2(CO2)[H])O
• InChI: 1S/C6H10O4/c7-5(3-1-9-3)6(8)4-2-10-4/h3-8H,1-2H2/t3-,4+,5+,6-
• InChI key: AAFJXZWCNVJTMK-GUCUJZIJSA-N

Beschreibung

Biochem/physiol Actions

Blood brain barrier penetrant alkylating agent that causes N7-guanine alkylation

Dianhydrogalactitol is a blood brain barrier penetrant and potent alkylating agent that causes N7-guanine alkylation and inter-strand DNA crosslinks that induces cell cycle arrest followed by apoptosis. Dianhydrogalactitol exhibits potent antitumor activity in number of clinical models including metastatic NSCLC resistant to TKI and glioblastoma multiforme.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable