SML3352

GSK973

≥98% (HPLC)

• Synonym(e): (2S,3S)-N5-((1R,5S,6r)-3-oxabicyclo[3.1.0]hexan-6-yl)-2-(fluoromethyl)-N7-methyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide
• Empirische Formel (Hill-System): C₂₃H₂₃FN₂O₄
• CAS-Nummer: 2138473-38-6
• Molekulargewicht: 410.44
• UNSPSC Code: 12352200
• MDL number: MFCD34471547
• NACRES: NA.21
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C

Beschreibung

Biochem/physiol Actions

Orally available, potent and selective pan-second bromodomain (BD2) inhibitor that effectively inhibits LPS-induced MCP-1 release in human whole blood.



GSK973 is an orally available, potent and selective pan-second bromodomain (BD2) inhibitor (BD2/BD1 pIC50 = 7.5/4.4/BRD2, 7.8/4.5/BRD3, 7.8/4.6/BRD4, 7.4/4.5/BRDT) that effectively inhibits LPS-induced MCP-1 release in human whole blood (pIC50 = 7.3; IC50 = 50 nM).

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• Was ist los?: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable