SML3460

CB-103

≥97% (HPLC)

• Synonym(e): 6-[4-(1,1-Dimethylethyl)phenoxy]-3-pyridinamine, CB 103, CB103
• Empirische Formel (Hill-System): C₁₅H₁₈N₂O
• CAS-Nummer: 218457-67-1
• Molekulargewicht: 242.32
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD00052647
• eCl@ss: 32160702
• Assay: ≥97% (HPLC)
• Form: powder

Eigenschaften

• Quality Segment: 100
• assay: ≥97% (HPLC)
• form: powder
• color: , White to very dark gray
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: -10 to -25°C
• SMILES string: Nc1cnc(cc1)Oc2ccc(cc2)C(C)(C)C
• InChI: 1S/C15H18N2O/c1-15(2,3)11-4-7-13(8-5-11)18-14-9-6-12(16)10-17-14/h4-10H,16H2,1-3H3
• InChI key: WHIWGRCYMQLLAO-UHFFFAOYSA-N

Beschreibung

Biochem/physiol Actions

CB-103 is an orally active Notch transcription activation inhibitor that targets RBPJ-Notch intracellular domain (NICD) transcription complex assembly. CB-103 exhibits antiproliferation efficacy against Notch-driven cancer growth in cultures (IC50 from 50 nM to 3 μM; patient-derived T-ALL cells positive for N1-ICD) and in tumor models in vivo (10-25 mg/kg qd or bid p.o. to mice with human T-ALL xenografts).

Orally active Notch transcription activation inhibitor with anti-cancer efficacy in cultures and in vivo.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable