SML3532

BAY-091

≥98% (HPLC)

• Synonym(e): (R)-2-(3-Cyano-2-(2′-fluoro-3′-methylbiphenyl-4-yl)-1,7-naphthyridin-4-ylamino)butanoic acid, BAY 091, BAY091
• Empirische Formel (Hill-System): C₂₆H₂₁FN₄O₂
• Molekulargewicht: 440.47
• UNSPSC Code: 12352200
• NACRES: NA.21
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: N#CC1=C(N=C2C=NC=CC2=C1N[C@H](CC)C(O)=O)C3=CC=C(C=C3)C4=C(C(C)=CC=C4)F
• InChI: 1S/C26H21FN4O2/c1-3-21(26(32)33)30-25-19-11-12-29-14-22(19)31-24(20(25)13-28)17-9-7-16(8-10-17)18-6-4-5-15(2)23(18)27/h4-12,14,21H,3H2,1-2H3,(H,30,31)(H,32,33)/t21-/m1/s1
• InChI key: DVIVLYHDLNAXAT-OAQYLSRUSA-N

Beschreibung

Biochem/physiol Actions

BAY-091 is a potent and highly selective PIP4K2A inhibitor (IC50 = 1.3/2.6 nM with 10/250 μM [ATP] by ADP-Glo, 8.5/16.4 nM with 10 μM/2 mM [ATP] by HTRF) with good cellular permeability (target engagement EC50 = 1.1 μM/intact cells vs 1.8 μM/cell lysate by CETSA) and no significant off-target activity as assessed by a 373-kinase panel (<60% inhibition at 1 μM).

Potent and highly selective PIP4K2A inhibitor with good cellular permeability and no significant off-target activity.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• Was ist los?: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable