SML3567

EN450

≥98% (HPLC)

• Synonym(e): N-(2-Chloro-5-(N,N-dimethylsulfamoyl)phenyl)acrylamide
• Empirische Formel (Hill-System): C₁₁H₁₃ClN₂O₃S
• CAS-Nummer: 793719-01-4
• Molekulargewicht: 288.75
• UNSPSC Code: 12352200
• NACRES: NA.21
• eCl@ss: 32150313
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: O=C(NC1=CC(S(=O)(N(C)C)=O)=CC=C1Cl)C=C
• InChI key: OXFXDOLAQBMOPH-UHFFFAOYSA-N

Beschreibung

Biochem/physiol Actions

Cysteine reactive UBE2D/NFKB1 molecular glue degrader; NFKB1 molecular glue degrader

EN450 is a molecular glue degraders of the oncogenic transcription factor NFKB1 that induces ternary complex formation between ubiquitin-conjugating enzyme E2D1 (UBE2D1) and NFKB1. EN450 covalently modifies an allosteric C111 in UBE2D1 and significantly reduces NFKB1 p105 levels. It impairs leukemia cell viability in a NEDDylation and proteasome-dependent manner at 50 µM.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable