SML3635

AGX51

≥98% (HPLC)

• Synonym(e): AGX 51, AGX-51, N-[3-(1,3-Benzodioxol-5-yl)-3-(2-methoxyphenyl)propyl]-N-(phenylmethyl)propenamide, N-[3-(1,3-Benzodioxol-5-yl)-3-(2-methoxyphenyl)propyl]-N-benzylpropanamide
• Empirische Formel (Hill-System): C₂₇H₂₉NO₄
• CAS-Nummer: 330834-54-3
• Molekulargewicht: 431.52
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD02241518
• Assay: ≥98% (HPLC)
• Form: oil

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: oil
• color: , colorless to light yellow
• storage temp.: 2-8°C

Beschreibung

Biochem/physiol Actions

AGX51 is an antagonist that blocks transcriptional regulators ID1-4 from binding basic helix-loop-helix (bHLH) transcription factor E47, causing ubiquitin-mediated degradation of IDs (10-40 μM for 2-48h; HCT116). AGX51 reduces cell viability, G0/G1 growth arrest, and a reduction in cyclin D1 levels in cultures (5-40 μM for 4-24h; HUVEC and HCT116) and suppresses ocular neovascularization in mouse models of age-related macular degeneration (AMD) and retinopathy of prematurity (ROP) in vivo (500 μg/mouse via twice daily i.p. or 1-30 μg/eye via intravitreal injection immediately and 7 days after rupture of Bruch’s membrane).

Antagonist that blocks transcriptional regulators ID1-4 from binding basic helix-loop-helix (bHLH) transcription factor E47, causing ubiquitin-mediated ID degradation.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• Was ist los?: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable