SML3678

ML-SI3

≥98% (HPLC), TRPML1/2 channel inhibitor, powder

• Synonym(e): N-[2-[4-(2-Methoxyphenyl)-1-piperazinyl]cyclohexyl]benzenesulfonamide
• Empirische Formel (Hill-System): C₂₃H₃₁N₃O₃S
• CAS-Nummer: 891016-02-7
• Molekulargewicht: 429.58
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD14811190
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Produktname: ML-SI3, ≥98% (HPLC)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: -10 to -25°C

Beschreibung

Biochem/physiol Actions

Four-diastereomer racemate with a cation channel TRPML1-blocking and TRPML2-activating activity, while exhibiting much weaker TRPML3 potency

ML-SI3 is a 4-diastereomer racemate (2 cis and 2 trans isomers) with a cation channel TRPML1-blocking (IC50 = 3.1 μM/trans, 18.5 μM/cis against 5 μM ML-SA1-induced cellular calcium response) and TRPML2-activating activity (EC50 = 3.3 μM/trans, 9.4 μM/cis), while exhibiting much weaker TRPML3 potency (EC50 = 28.5 μM/trans, IC50 = 29.0 μM/cis). ML-SI3 is shown to compete against ML-SA1 for binding the same TRPML1 hydrophobic cavity. Comparing with ML-SI1 (GW405833), ML-SI3 is more potent and not agonist-dependent, effectively antagonizing against TRPML1 activation by both MK6-83 and ML-SA1.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable