SML3712

NG-497

≥98% (HPLC)

• Synonym(e): 6-(4-Ethoxyphenyl)-4-methoxy-2-pyridinecarboxylic acid, 1-methylethyl ester, Isopropyl 6-(4-ethoxyphenyl)-4-methoxypicolinate, NG 497, NG497
• Empirische Formel (Hill-System): C₁₈H₂₁NO₄
• CAS-Nummer: 2598242-66-9
• Molekulargewicht: 315.36
• UNSPSC Code: 51111800
• NACRES: NA.25
• eCl@ss: 32160701
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: O=C(C1=CC(OC)=CC(C2=CC=C(OCC)C=C2)=N1)OC(C)C
• InChI: 1S/C18H21NO4/c1-5-22-14-8-6-13(7-9-14)16-10-15(21-4)11-17(19-16)18(20)23-12(2)3/h6-12H,5H2,1-4H3
• InChI key: VYEIBLWRGBQRPI-UHFFFAOYSA-N

Beschreibung

Biochem/physiol Actions

NG-497 is a non-cytotoxic, substrate-competitive, reversible and highly selective human/primate adipose triglyceride lipase (ATGL; IPLA2-zeta; PNPLA2) inhibitor (IC50 = 1 μM, Ki = 0.5 μM) with little activity toward related human lipid hydrolases or ATGL orthologues from other species (<20% inhibition of mouse, rat, goat, pig, dog, marmoset ATGL at 50 μM). NG-497 abolishes hormone-induced lipolysis in human adipocytes (IC50 = 1.5 and 0.5 μM against 1 μM isoproterenol-induced total or hormonesensitive lipase (HSL)-independent FA release in Simpson-Golabi-Behmel syndrome adipocytes), but not in HepG2 that lacks ATGL hydrolase activity.

Non-cytotoxic, substrate-competitive, reversible and highly selective human/primate adipose triglyceride lipase (ATGL; IPLA2-zeta; PNPLA2) inhibitor.

Sicherheitshinweise

• Lagerklasse: 10 - Combustible liquids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable