SML3733

BAY-0069

≥98% (HPLC)

• Synonym(e): 2-Bromo-N-[2-(4-ethylphenyl)-1,3-benzoxazol-5-yl]-5-nitrobenzamide, BAY 0069, BAY0069
• Empirische Formel (Hill-System): C₂₂H₁₆BrN₃O₄
• CAS-Nummer: 420826-65-9
• Molekulargewicht: 466.28
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD02210188
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C

Beschreibung

Biochem/physiol Actions

BAY-0069 is a potent and selective covalent PPARγ inverse agonist (IC50 = 0.22 nM, max inhibition = 88% by cell-based reporter assays) that induces interactions between the PPARγ ligand-binding domain (LBD) and the corepressor NCOR2 (EC50 = 9.6 nM, Emax = 620% by TR-FRET). BAY-0069 exhibits anti-proliferation efficacy against PPARγ-dependent growth in cultures (UM-UC9 IC50 = 2.5 nM, max inhibition = 72%).

Potent and selective covalent PPARγ inverse agonist with anti-proliferation efficacy against PPARγ-dependent growth in cultures.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• Was ist los?: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable