SML4024

PZ-1922

≥95% (HPLC)

• Synonym(e): 1-(3-Chlorobenzyl)-4-(piperazin-1-yl)-1H-pyrrolo[3,2-c]quinoline hydrochloride, 1-[(3-Chlorophenyl)methyl]-4-(1-piperazinyl)-1H-pyrrolo[3,2-c]quinoline hydrochloride, PZ 1922 hydrochloride, PZ1922 hydrochloride
• Empirische Formel (Hill-System): C₂₂H₂₁ClN₄ · xHCl
• CAS-Nummer: 1648744-85-7
• Molekulargewicht: 376.88 (free base basis)
• UNSPSC Code: 12352200
• NACRES: NA.21
• Assay: ≥95% (HPLC)
• Form: powder
• Storage condition: desiccated

Eigenschaften

• Quality Segment: 100
• assay: ≥95% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: -10 to -25°C
• SMILES string: ClC1=CC(CN2C=CC3=C2C4=CC=CC=C4N=C3N5CCNCC5)=CC=C1
• InChI key: MFUVKDHSDIAPMH-UHFFFAOYSA-N

Beschreibung

Biochem/physiol Actions

Bioavailable triple acting, selective, high affinity 5-HT6R/5-HT3R dual antagonist and MAO-B reversible inhibitor; anti-AD agent.

PZ-1922 is a piperazinyl-pyrroloquinoline analog with favorable oral absorption and CNS penetration that simultaneously targets 5-HT6R (Ki = 17 nM), 5-HT3R (Ki = 0.45 nM), and MAO-B (pIC50 = 8.93). PZ1922 shows high selectivity over a selected panel of GPCRs, MAO-A and hERG. PZ 1922 effectively reverses cognitive impairment, prevents Aβ-induced memory decline in rodent models of Alzheimer’s disease (AD) (1.5 mg/kg/ip injection) and modulates neuroinflammatory processes.

Disclaimer

Hygroscopic

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• Was ist los?: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable