SML4039

SCH-527123

≥98% (HPLC)

• Synonym(e): 2-Hydroxy-N,N-dimethyl-3-[[2-[[(1R)-1-(5-methyl-2-furanyl)propyl]amino]-3,4-dioxo-1-cyclobuten-1-yl]amino]benzamide, 2-Hydroxy-N,N-dimethyl-3-[[2-[[(1R)-1-(5-methylfuran-2-yl)propyl]amino]-3,4-dioxocyclobuten-1-yl]amino]benzamide, 3-[[3-[(Dimethylamino)carbonyl]-2-hydroxyphenyl]amino]-4-[[(R)-1-(5-methylfuran-2-yl)propyl]amino]cyclobut-3-ene-1,2-dione, CXCR2 Antagonist IV, MK 7123, MK-7123, MK7123, Navarixin, PS 291822, PS-291822, PS291822, SCH 527123, SCH527123
• Empirische Formel (Hill-System): C₂₁H₂₃N₃O₅
• CAS-Nummer: 473727-83-2
• Molekulargewicht: 397.42
• MDL number: MFCD16628072
• NACRES: NA.21
• UNSPSC Code: 12352200
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: N([C@H](CC)c3[o]c(cc3)C)c1[c]([c](c1Nc2c(c(ccc2)C(=O)N(C)C)O)=O)=O
• InChI key: RXIUEIPPLAFSDF-CYBMUJFWSA-N

Beschreibung

Biochem/physiol Actions

Orally active, high-affinity, potent and selective allosteric CXCR2 antagonist.

SCH-527123 is an orally active, high-affinity, potent and selective allosteric CXCR2 antagonist (IC50 = 2.6 nM) with much reduced CXCR1 potency (IC50 = 36 nM) and little activity against a large panel of enzymes, channels, and GPCRs (IC50 >10 µM). SCH-527123 blocks CXCL8- and CXCL1-induced human neutrophil (hPMN) chemotaxis in cultures (IC50 = 16 & <1 nM, respectively) and pulmonary neutrophilia in vivo (ED50 = 1.2 mg/kg mouse, 1.8 mg/kg rat p.o.) following intranasal LPS administration.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable