SML4071

BAY-593

≥95% (HPLC)

• Synonym(e): (R)-3,3,3-Trifluoro-2-methoxy-1-((R)-7-(2-methoxyphenyl)-3,9-diazaspiro[5.5]undecan-3-yl)-2-phenylpropan-1-one, (2R)-3,3,3-Trifluoro-2-methoxy-1-[(7R)-7-(2-methoxyphenyl)-3,9-diazaspiro[5.5]undec-3-yl]-2-phenyl-1-propanone, BAY 593, BAY593, GGTase-I inhibitor BAY-593, YAP1/TAZ pathway inhibitor BAY-593
• Empirische Formel (Hill-System): C₂₆H₃₁F₃N₂O₃
• CAS-Nummer: 2413020-56-9
• Molekulargewicht: 476.53
• UNSPSC Code: 12352200
• Assay: ≥95% (HPLC)
• Form: powder

Eigenschaften

• Quality Segment: 100
• assay: ≥95% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: -10 to -25°C

Beschreibung

Biochem/physiol Actions

BAY-593, a GGTase-I inhibitor, primarily targets the YAP1/TAZ signaling pathway, a crucial axis in cell proliferation and tumor progression. Notably, BAY593 alters the mRNA expression levels of YAP1/TAZ target genes including CYR61, CTCF, ANKRD1, and CD274, indicating its specific molecular action. In vitro studies reveal its IC50 values: 9.41 nM for MDA-MB-231 TEAD-luc, 0.564 µM for MDA-MB-231 proliferation, and 38.4 nM for HT-1080 proliferation. The efficacious in vivo dose was determined as 5 mg/kg (p.o., BID), in the PXF 541 pleuromesothelioma xenograft model, showcasing its therapeutic potential in cancer treatment.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable