SML4095

Motolimod

≥98% (HPLC)

• Synonym(e): VTX 378, VTX-2337, 2-Amino-N,N-dipropyl-8-[4-(1-pyrrolidinylcarbonyl)phenyl]-3H-1-benzazepine-4-carboxamide, 2-Amino-N,N-dipropyl-8-[4-(pyrrolidine-1-carbonyl)phenyl]-3H-1-benzazepine-4-carboxamide, 2-Amino-N,N-dipropyl-8-[4-(pyrrolidine-1-carbonyl)phenyl]-3H-benzo[b]azepine-4-carboxamide, VTX 2337, VTX2337, VTX378
• Empirische Formel (Hill-System): C₂₈H₃₄N₄O₂
• CAS-Nummer: 926927-61-9
• Molekulargewicht: 458.60
• MDL number: MFCD28044318
• NACRES: NA.21
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear (Warmed)
• storage temp.: 2-8°C
• SMILES string: N4(CCCC4)C(=O)c1ccc(cc1)c2cc3c(cc2)C=C(C=C(N3)N)C(=O)N(CCC)CCC
• InChI: 1S/C28H34N4O2/c1-3-13-31(14-4-2)28(34)24-17-23-12-11-22(18-25(23)30-26(29)19-24)20-7-9-21(10-8-20)27(33)32-15-5-6-16-32/h7-12,17-19,30H,3-6,13-16,29H2,1-2H3
• InChI key: CQAGPRVMJDWWEA-UHFFFAOYSA-N

Beschreibung

Biochem/physiol Actions

Potent and selective toll-like receptor 8 (TLR8) agonist that augments the lytic function of NK cells and enhances antibody-dependent cellular cytotoxicity.
Motolimod (VTX-2337) is a potent and selective human toll-like receptor 8 (TLR8) agonist (EC50 = 100 nM; no murine TLR8-stimulating potenty) with greatly reduced TLR7 potency (EC50 >30 µM) and little activity toward TLR3/4/5/8. Motolimod induces proinflammatory mediators production in huaman PBMCs (TNFα/IL12 EC50 = 140/120 nM) by stimulating TLR8-expressing monocytes and mDCs, but not non-TLR8-expressing pDCs. Motolimod augments the lytic function of NK cells and enhances antibody-dependent cellular cytotoxicity (ADCC).

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• Was ist los?: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable