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Über diesen Artikel
Empirische Formel (Hill-System):
C19H14FNO
CAS-Nummer:
Molekulargewicht:
291.32
MDL number:
NACRES:
NA.28
UNSPSC Code:
12352200
Assay:
≥98% (HPLC)
Form:
powder
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Unterstützung erhaltenQuality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
FC1=CC=C(C(NC2=CC=C3C4=C2C=CC=C4CC3)=O)C=C1
Biochem/physiol Actions
Uniquely acting, highly selective sub-type activator for the KCNQ2 (KV7.2) potassium channel.
Ebio1 is a potent, sub-type selective KCNQ2 (KV7.2) potassium channel direct activator that is distinct from previously known activators of voltage-gated ion channels. Ebio1 operates through a unique mechanism, inducing a twist-to-open movement in the S6 helices of the channel, thereby increasing both the open probability and conductance of KCNQ2. KCNQ2 Activator Ebio1 has an EC50 of 247.3 nM for KCNQ2, making it tenfold more selective compared to KCNQ2/3, KCNQ4, and KCNQ5. Moreover, Ebio1 demonstrates minimal to negligible activation effects on other tested Kv, Nav, Cav, and K2P channel members, including hERG, BK, Nav1.1, Cav2.1, and TREK1.
Ebio1 is a potent, sub-type selective KCNQ2 (KV7.2) potassium channel direct activator that is distinct from previously known activators of voltage-gated ion channels. Ebio1 operates through a unique mechanism, inducing a twist-to-open movement in the S6 helices of the channel, thereby increasing both the open probability and conductance of KCNQ2. KCNQ2 Activator Ebio1 has an EC50 of 247.3 nM for KCNQ2, making it tenfold more selective compared to KCNQ2/3, KCNQ4, and KCNQ5. Moreover, Ebio1 demonstrates minimal to negligible activation effects on other tested Kv, Nav, Cav, and K2P channel members, including hERG, BK, Nav1.1, Cav2.1, and TREK1.
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Dieser Artikel | |||
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| description ≥98% (HPLC) | description affinity isolated antibody | description Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution | description ≥98% (HPLC) |
| form powder | form buffered aqueous solution | form buffered aqueous glycerol solution | form powder |
| assay ≥98% (HPLC) | assay - | assay - | assay ≥98% (HPLC) |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| storage temp. 2-8°C | storage temp. −20°C | storage temp. −20°C | storage temp. 2-8°C |
| solubility DMSO: 2 mg/mL, clear | solubility - | solubility - | solubility DMSO: 25 mg/mL, clear |
| color white to beige | color - | color - | color , light to dark purple |
Lagerklasse
11 - Combustible Solids
Was ist los?
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
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