SML4223

Artepillin C

≥98% (HPLC), powder, CREB-CRTC2 inhibitor

• Synonym(e): (2E)-3-[4-Hydroxy-3,5-bis(3-methyl-2-buten-1-yl)phenyl]-2-propenoic acid
• Empirische Formel (Hill-System): C₁₉H₂₄O₃
• CAS-Nummer: 72944-19-5
• Molekulargewicht: 300.39
• MDL number: MFCD27664995
• NACRES: NA.21
• UNSPSC Code: 12352200
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C

Beschreibung

General description

Artepillin C (ARC) is a prenylated derivative of p-coumaric acid. It is one of the primary phenolic compounds present in Brazilian green propolis (BGP) and Baccharis dracunculifolia. It is a p-CA derivative, featuring two prenyl groups linked to the meta-positions (C3 and C5) of the phenyl ring.

Application

Artepillin C may be used to investigate its interaction with human serum albumin (HSA) and to understand its physicochemical transport mechanism in vitro.

Biochem/physiol Actions

Phenolic component of propolis that exhibits multiple activities including anti-inflammatory, anti-tumor, antimicrobial and antioxidant activities; inhibitor of CREB-CRTC2 interaction. The anti-cancer properties of ARC are due to several mechanisms, including the induction of apoptosis, cell cycle arrest, and the inhibition of p21-activated kinase 1 (PAK1).

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• Was ist los?: WGK 3