SML4284

Fumarate hydratase-IN-1

≥98% (HPLC), powder, fumarate hydratase inhibitor

• Synonym(e): rel- Ethyl (3S,3aR)-1-([1,1′-biphenyl]-4-ylmethyl)-3-(2-(methylamino)-2-oxoethyl)-2-oxo-1,2,3,4,5,6-hexahydro-3aH-indole-3a-carboxylate
• Empirische Formel (Hill-System): C₂₇H₃₀N₂O₄
• CAS-Nummer: 1644060-37-6
• Molekulargewicht: 446.54
• UNSPSC Code: 12352200
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: -10 to -25°C

Beschreibung

Application

Fumarate hydratase-IN-1 may be used:

• to study its effects on mitochondrial bioenergetics and macrophage metabolism
• to assess its regulatory effects in LPS-induced acute lung injury (ALI) models
• to study the role of fumarate in immunomodulation and regulating type I interferon production after viral infection

Biochem/physiol Actions

FHIN1 exhibits nutrient-dependent antiproliferation activity in cancer cultures (mean IC50 = 2.2 µM in glucose-free L-15 medium; SW620, ACHN, HCT-116, PC3, SK-MEL-28) by targeting tricarboxylic acid (TCA) cycle without blocking mitochondrial electron-transport chain (ETC) or ATP synthase.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable