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Über diesen Artikel
Empirische Formel (Hill-System):
C14H12ClF2NO2S
CAS-Nummer:
Molekulargewicht:
331.77
UNSPSC Code:
12352200
Assay:
≥98% (HPLC)
Form:
powder
Preise und Verfügbarkeit sind derzeit nicht verfügbar.
Technischer Dienst
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Unterstützung erhaltenQuality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
General description
Cell penetrant, selective and potent activator of telomerase reverse transcriptase (TERT).
TAC (TERT activator compound) is a cell penetrant, selective and potent activator of telomerase reverse transcriptase (TERT) that upregulates TERT transcription through activation of the MEK/ERK/AP-1 cascade. It induces TERT expression in WS fibroblasts (0.5 µM) and increases telomere synthesis in primary human cells. TAC alleviates neuroinflammation, increases neurotrophic factors, stimulates adult neurogenesis, and preserves cognitive function without toxicity in brain of naturally aged mice.
TAC (TERT activator compound) is a cell penetrant, selective and potent activator of telomerase reverse transcriptase (TERT) that upregulates TERT transcription through activation of the MEK/ERK/AP-1 cascade. It induces TERT expression in WS fibroblasts (0.5 µM) and increases telomere synthesis in primary human cells. TAC alleviates neuroinflammation, increases neurotrophic factors, stimulates adult neurogenesis, and preserves cognitive function without toxicity in brain of naturally aged mice.
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| description ≥98% (HPLC) | description certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland | description NOTE: Both the cell line and DNA from the cell line may be available for this product. Please choose -1VL or VIAL for cells, or -DNA-5UG for DNA. | description ≥99% |
| assay ≥98% (HPLC) | assay - | assay - | assay ≥99% |
| form powder | form - | form - | form - |
| Quality Level 100 | Quality Level 300 | Quality Level - | Quality Level 200 |
| storage temp. -10 to -25°C | storage temp. −20°C | storage temp. −196°C | storage temp. - |
| solubility DMSO: 2 mg/mL, clear | solubility - | solubility - | solubility - |
| color white to beige | color - | color - | color - |
Lagerklasse
11 - Combustible Solids
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
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