SML4368

SerBut

≥98% (HPLC)

• Synonym(e): (2S)-2-Amino-3-(butanoyloxy)propanoic acid hydrochloride, O-(1-Oxobutyl)-L-serine, O-Butyryl-L-serine hydrochloride, O-Butyryl-L-Ser hydrpchloride
• Empirische Formel (Hill-System): C₇H₁₃NO₄·HCl
• CAS-Nummer: 1312366-50-9
• Molekulargewicht: 211.64
• UNSPSC Code: 12352203
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: desiccated

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to beige
• solubility: H₂O: 2 mg/mL, clear
• storage temp.: 2-8°C

Beschreibung

Biochem/physiol Actions

SerBut (O-butyryl-L-serine) is an orally available, serine-conjugated butyrate precursor with therapeutic efficacy against autoimmune arthritis and neuroinflammation in vivo in mouse models of collagen antibody-induced arthritis (CAIA) (anti-collagen mAb on day 0, LPS i.p. on day 3, daily 20 mg SerBut/mouse p.o. starting on day -14 or twice daily 25 mg SerBut/mouse p.o. starting on day 4) and experimental autoimmune encephalomyelitis (EAE) (MOG35-55/CFA + PTX on day 0, daily 24 mg SerBut/mouse p.o. starting on day 2 with or twice daily 24 mg SerBut/mouse p.o. starting on day 2 without 100 mM SerBut in drinking water throughout starting day -14).

Disclaimer

Hygroscopic Store with desiccant

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable