SML4417

USP30-I-1

≥98% (HPLC)

• Synonym(e): N-((3R,5R)-1-Cyano-5-methylpyrrolidin-3-yl)-5-(3-cyanophenyl)oxazole-2-carboxamide, USP30 Inhibitor-1, USP30-IN-1
• Empirische Formel (Hill-System): C₁₇H₁₅N₅O₂
• CAS-Nummer: 2511541-78-7
• Molekulargewicht: 321.33
• UNSPSC Code: 12352200
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: -10 to -25°C

Beschreibung

Biochem/physiol Actions

USP30-I-1 is a potent and selective cyanopyrrolidine-based covalent inhibitor of the mitochondrial deubiquitinase USP30, designed to enhance mitophagy by targeting the catalytic cysteine (Cys77) with high specificity at concentrations ≤1 μM. USP30-I-1 demonstrates dose-dependent inhibition with an IC50 of 94 nM in neuroblastoma cells, efficiently blocking USP30 activity with no significant toxicity reported in the tested models and no adverse effects on non-target proteins within the tested concentration range. USP30-I-1’s kinetic profile (kinact/KI = 0.18 μM⁻¹s⁻¹) highlights its effective covalent bond formation, while in vitro studies confirm its ability to disrupt ubiquitin-substrate interactions essential for mitophagy regulation.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable