SML4431

SALAD1

≥98% (HPLC)

• Synonym(e): (E)-3-(2-((2-Fluoro-6-(1H-pyrazol-1-yl)benzyl)amino)-2-oxoethyl)-2-((1-methylquinolin-4(1H)-ylidene)methyl)benzo[d]thiazol-3-ium, 2,2,2-trifluoroacetate, 365A-061, MangoBright RNA Fluor
• Empirische Formel (Hill-System): C₃₀H₂₅FN₅OS·CF₃CO₂ · xC₂HF₃O₂
• Molekulargewicht: 635.63 (free base basis)
• UNSPSC Code: 12352200
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: desiccated

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: light orange to dark orange
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: -10 to -25°C

Beschreibung

Biochem/physiol Actions

SALAD1 (structure-informed, array-enabled LigAnD 1) is a cell-permeable, photostable, and ultrabright RNA-activated fluorophore. SALAD1 specifically and reversibly targets the Mango II aptamer (KDapp = 0.69 nM) with high selectivity. Upon binding, SALAD1 shows a remarkable 1,500-fold increase in fluorescence (λex 511 nm, λem 540 nm; Φ = 0.722, ε = 47,284 M⁻¹ cm⁻¹). This enables superior real-time confocal RNA imaging within living cells. Furthermore, the Mango III–SALAD1 complex, while binding less tightly, offers even greater brightness, expanding its potential for diverse live-cell imaging applications.

Disclaimer

Hygroscopic, Store with desiccant

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable