Stability of stock solutions of this product has not been specifically tested. General information for thiamphenicol indicates that stock solutions may be stored at -20 °C for up to one month or at -80 °C for up to one year. Prepare single-use aliquots to avoid repeated freeze-thaw cycles.
Fortfahren mit
T0261
Thiamphenicol
Synonym(e):
Raceophenidol, Thiophenicol, D-threo-2,2-Dichloro-N-(β-hydroxy-α-[hydroxymethyl]-4-[methylsulfonyl]phenethyl)acetamide
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Über diesen Artikel
Empirische Formel (Hill-System):
C12H15Cl2NO5S
CAS-Nummer:
Molekulargewicht:
356.22
UNSPSC Code:
51284303
NACRES:
NA.85
PubChem Substance ID:
EC Number:
239-355-3
Beilstein/REAXYS Number:
2819542
MDL number:
eCl@ss:
32160701
Preise und Verfügbarkeit sind derzeit nicht verfügbar.
Technischer Dienst
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Unterstützung erhaltenform
powder
Quality Segment
color
white to off-white
solubility
ethanol: soluble 50 mg/mL
antibiotic activity spectrum
Gram-negative bacteria, Gram-positive bacteria
mode of action
protein synthesis | interferes
SMILES string
CS(=O)(=O)c1ccc(cc1)[C@@H](O)[C@@H](CO)NC(=O)C(Cl)Cl
InChI
1S/C12H15Cl2NO5S/c1-21(19,20)8-4-2-7(3-5-8)10(17)9(6-16)15-12(18)11(13)14/h2-5,9-11,16-17H,6H2,1H3,(H,15,18)/t9-,10-/m1/s1
InChI key
OTVAEFIXJLOWRX-NXEZZACHSA-N
General description
Chemical structure: phenicole
Application
Thiamphenicol is an antibiotic that has been used to treat chancroid in men and uncomplicated gonorrhea. It is used in studies of bacterial protein synthesis at the level of peptidyl transferase activity associated with the 23S rRNA of the 50S ribosomal subunit. It is used to study chloraniphenicol-thiamphenicol-resistance and the use of fluorinated analogs when resistance is encountered.
Biochem/physiol Actions
Thiamphenicol inhibits mitochondrial protein synthesis of proteins such as cytochrome c oxidase.
Packaging
1G,5G,25G
Other Notes
Keep container tightly closed in a dry and well-ventilated place.
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Dieser Artikel | |||
|---|---|---|---|
| description - | description - | description European Pharmacopoeia (EP) Reference Standard | description analytical standard |
| mode of action protein synthesis | interferes | mode of action - | mode of action - | mode of action - |
| antibiotic activity spectrum Gram-positive bacteria, Gram-negative bacteria | antibiotic activity spectrum - | antibiotic activity spectrum - | antibiotic activity spectrum - |
| Quality Level 100 | Quality Level - | Quality Level - | Quality Level 100 |
| form powder | form - | form - | form - |
| solubility ethanol: soluble 50 mg/mL | solubility - | solubility - | solubility ethanol: 50 mg/mL, clear, colorless to faintly yellow |
| color white to off-white | color - | color - | color - |
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Lagerklasse
11 - Combustible Solids
WGK
WGK 2
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
PSA (Persönliche Schutzausrüstung)
Eyeshields, Gloves, type N95 (US)
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