T4952

Tanshinon IIA

≥97% (HPLC)

• Synonym(e): 1,6,6-Trimethyl-6,7,8,9-tetrahydrophenanthro[1,2-b]furan-10,11-dion, Dan Shen-Keton
• Empirische Formel (Hill-System): C₁₉H₁₈O₃
• CAS-Nummer: 568-72-9
• Molekulargewicht: 294.34
• NACRES: NA.25
• PubChem Substance ID: 329826804
• UNSPSC Code: 12352212
• MDL number: MFCD00238692

Eigenschaften

• Quality Segment: 100
• assay: ≥97% (HPLC)
• form: powder
• color: orange to dark red
• solubility: methanol: 5 mg/mL, clear, red-orange to red
• application(s): metabolomics; vitamins, nutraceuticals, and natural products
• storage temp.: 2-8°C
• SMILES string: Cc1coc2-c3ccc4c(CCCC4(C)C)c3C(=O)C(=O)c12
• InChI: 1S/C19H18O3/c1-10-9-22-18-12-6-7-13-11(5-4-8-19(13,2)3)15(12)17(21)16(20)14(10)18/h6-7,9H,4-5,8H2,1-3H3
• InChI key: HYXITZLLTYIPOF-UHFFFAOYSA-N

Beschreibung

General description

Tanshinone IIA (Tan IIA) is a natural diterpene quinone, a lipophilic component derived from the root extract of Salvia miltiorrhiza.

Application

Tanshinone IIA has been used:

• to test its effect on osteoclast differentiation in ovariectomy-induced osteoporosis mouse model
• to test its effects on microglia and to study its neuroprotective effect on ischemia-reperfusion injured rat brain
• to study its effects on the proliferation, apoptosis, and autophagy of acute myeloid leukemia (AML) in vitro and in vivo models
• to investigate its anti-inflammatory and protective effects on ATDC5 cells from lipopolysaccharide (LPS)-induced inflammatory injury

Biochem/physiol Actions

Tanshinone IIA provides protective effects against cardiovascular diseases by enhancing angiogenesis. It elicits neuroprotective, anti-cancer, anti-diabetic, and anti-obesity properties. Tan-IIA plays a significant role in modulating the development and function of immune cells.

Phenanthrenchinon ist ein Bestandteil der chinesischen Heilpflanze Danshen (Salvia miltiorrhiza). Antiphlogistikum, Antioxidanz, Zytotoxische gegen eine Vielzahl von Zelllinien, einschliesslich menschliche Gliom-Zellen.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• Was ist los?: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• PSA (Persönliche Schutzausrüstung): Eyeshields, Gloves, type N95 (US)