T5330

Tanshinone I

≥98% (HPLC)

• Synonym(e): Tanshinon A
• Empirische Formel (Hill-System): C₁₈H₁₂O₃
• CAS-Nummer: 568-73-0
• Molekulargewicht: 276.29
• NACRES: NA.25
• PubChem Substance ID: 329826820
• UNSPSC Code: 12352205
• MDL number: MFCD00210563
• eCl@ss: 32160703

Eigenschaften

• Quality Segment: 200
• assay: ≥98% (HPLC)
• form: powder
• color: red
• solubility: DMSO: 1 mg/mL
• application(s): metabolomics; vitamins, nutraceuticals, and natural products
• storage temp.: 2-8°C
• SMILES string: Cc1coc2-c3ccc4c(C)cccc4c3C(=O)C(=O)c12
• InChI: 1S/C18H12O3/c1-9-4-3-5-12-11(9)6-7-13-15(12)17(20)16(19)14-10(2)8-21-18(13)14/h3-8H,1-2H3
• InChI key: AIGAZQPHXLWMOJ-UHFFFAOYSA-N

Beschreibung

General description

Tanshinone I (Tan I) is a phenolic compound primarily isolated from Danshen. It has an abietane diterpene norditerpenoid o-quinones structure. Tan I have poor water solubility.

Application

Tanshinone 1 has been used:

• to test its hematopoiesis effects on human leukemia cell lines and zebrafish xenograft models
• to study its anti-cancer effects on two breast cancer cell lines (MCF7 and MDA-MB-23)
• as a reference standard to quantify the bioactive component S. miltiorrhiza extract (SME) using high-performance liquid chromatography (HPLC)

Biochem/physiol Actions

Phenanthrenchinon ist ein Bestandteil der chinesischen Heilpflanze Danshen (Salvia miltiorrhiza). Moduliert oder verhindert Metastasierung von Brustkrebs durch die Regelung der Adhäsionsmoleküle. Entzündungshemmend.

Phenanthrenequinone constituent of Chinese medicinal herb Danshen (Salvia miltiorrhiza). Modulates or prevents breast cancer metastasis by regulating adhesion molecules.Anti-inflammatory.

TanshinoneI is extensively studied for its anticancer properties, it was reported to inhibit cancer cell invasion, metastasis, and migration and is a potent antitumor agent. It also displays antibacterial, neuroprotective, memory-enhancing, and cardioprotective activities.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable